We have changed our recomendations for gastroprotectants, particularly for non-steroidal anti-inflammatory drug (NSAID) overdose, in line with the American College of Veterinary Internal Medicine (ACVIM) consensus statement.
With respect to gastroprotectants for the management of gastroduodenal ulceration and erosion the concensus is that proton pump inhibitors are superior to H2-receptor antagonists, sucralfate, and misoprostol for most causes of gastroduodenal ulceration and erosion in people and should be considered as standard of care for the medical treatment of gastroduodenal ulceration and erosion in dogs and cats.
There are two other points to note:
- If proton pump inhibitors are used, twice‐daily administration is superior to once‐daily administration to achieve goals of acid suppression for treatment of gastroduodenal ulceration and erosion.
- There is no evidence of benefit of administration of an H2-receptor antagonists with a proton pump inhibitor for ulcer healing, and this combination may diminish the effectiveness of the proton pump inhibitor.
The position statement is accessible free online.